Gene X Two Triple Mutations Predominance on Chronic Hepatitis B Virus in Padang, West Sumatra Indonesia

Background: Hepatitis B is a health issue that become major problem worldwide with high morbidity. liver infection caused by Virus. Chronic hepatitis inflammation lasted more than 6 months and it has the potential to progress cirrhosis hepatocellular cancer. The disease influenced Gene X viral genotype. Mutations in are suspected having role progression. aim of this study was detect polymorphism phylogeny HBV from Padang local clinical samples chronic (CHB), West Sumatera, Indonesia.Method: entire chronically HBV-infected patients were enrolled study: 38 CHB. research serum Indonesian Red Cross Blood Bank amplified using nested PCR, which produced two fragments aligned sequence database continued mutation analysis. Results: In we found all nucleotide variation. Of various mutations, observed presence known HCC-related HBx protein mutant i.e double mutations (HBx130 HBx131) triple (HBx5/HBx130/HBx131) (HBx127/HBx130/HBx131) high. analysis also showed infected mainly genotype C at 72,2% followed 27,8%.Conclusion: We conclude have variation implying molecular progression between virus host patients.